Physicochemical Characterization of 9-Aminocamptothecin in Aqueous Solutions
نویسندگان
چکیده
منابع مشابه
Pharmacological determinants of 9-aminocamptothecin cytotoxicity.
The camptothecins are a group of anticancer agents with a unique mechanism of action: poisoning of eukaryotic DNA topoisomerase I. 9-aminocamptothecin (9-AC), a potent water-insoluble derivative of camptothecin, is currently undergoing clinical testing. The kinetics of the active derivative 9-AC lactone in cell culture media was defined, and then 9-AC cytotoxicity against human breast (MCF-7), ...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2013
ISSN: 1530-9932
DOI: 10.1208/s12249-013-0046-y